Incomplete IgG avidity maturation after seasonal coronavirus infections

In classical viral infections, the avidity of immunoglobulin G (IgG) is low during acute infection and high a few months later. As recently reported, SARS-CoV-2 infections are not following this scheme, but they rather characterized by incomplete maturation. This study was performed to clarify whether with seasonal coronaviruses also leads The IgG toward nucleoprotein (NP) 229E, NL63, OC43, HKU1 determined in sera from 88 healthy, SARS-CoV-2-negative subjects 70 COVID-19 outpatients, using recomLine assay recombinant antigens. subjects, maturation (persistent intermediate indices) lowest for alpha-coronaviruses 229E (33.3%) NL63 (61.3%), highest beta-coronaviruses OC43 (77.5%) (71.4%). patients, degree NP 223E, significantly different that found significant increase observed NL63. Though there no cross-reaction between coronaviruses, higher concentrations directed seemed indirectly SARS-CoV-2. Our data show represents characteristic consequence coronavirus infections. raises problems serological differentiation past may be important biology coronaviruses.